Testing Status of Methyl ethyl ketone peroxide 10001-N

 

CASRN: 1338-23-4

Formula: C8-H14-O4

Synonyms/Common Names

  • 2-Butanone, peroxide

Known Uses

Hardening agent for fiberglass reinforced plastics. Curing agent for unsaturated polyester resins.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C55447B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 50.6, 101.3, 202.5, 405, OR 810 MG/KG; M: 0, 112.5, 225, 450, 900, OR 1800 MG/KG (5/S/S).
  • 13 weeks (Topical Application)  (C55447B)  Report Complete 
    • TOX-18 (NIH Number: 93-3341)
      Toxicity Studies of Methyl Ethyl Ketone Peroxide (CASRN 1338-23-4) in Dimethyl Phthalate (CASRN 131-11-3) (45:55)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1.07, 3.57, 10.7, 35.7, OR 107 MG/ANIMAL; M: 0, 0.357, 1.19, 3.57, 11.9, OR 35.7 MG/ANIMAL (10/S/S).

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (774268)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (091264)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (A70805)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (594981)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (784039)  Completed 
    •  Positive