National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10003-w

Testing Status of Glutaraldehyde - 10003-W

 

CASRN: 111-30-8

Formula: C5-H8-O2

Synonyms/Common Names

  • Pentanedial (9CI)

Known Uses

Disinfectant and sterilizing agent. Embalming fluid. Chemical intermediate for adhesives, electrical products, tanning soft leathers (HSDB 1990). In photographic developing, dental materials.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C55425B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.16, 0.5, 1.6, 5 OR 16 PPM (5/S/S).
  • 13 weeks (Inhalation)  (C55425B)  Report Complete 
    • TOX-25 (NIH Number: 93-3348)
      Toxicity Studies of Glutaraldehyde (CASRN 111-30-8) Adminstered by Inhalation to F344/N Rats and B6C3F1 Mice.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 62.5, 125, 250, 500 OR 1000 PPB (10/S/S).

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C55425C)  Report Complete 
    • TR-490 (NIH Number: 99-3980)  (Peer Review Approval 10/30/1998A )
      Toxicology and Carcinogenesis Studies of Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 250, 500, OR 750 PPB; 50/SEX/GROUP M: 0, 62.5, 125, OR 250 PPB; 50/SEX/ GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (212368)  Completed 
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (004326)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (146021)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Weakly Positive 
  • Drosophila  (779687)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (887025)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (558174)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Micronucleus  (212368)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Micronucleus  (462636)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A57716)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (502523)  Completed 
    •  Positive 
  • Salmonella  (684635)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Equivocal 
  • Salmonella  (761374)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 

Organ Systems Toxicity

  • 5 days (mice) and 14 days (guinea pigs) Immunotoxicity (Topical Application)  (IMM87098)  Completed 
    • Female Mice: B6C3F1
    • Dose: M: 0, 0.03, 0.1, 0.3, 1.0, 3.0, OR 10%; GP: 0, 0.3, 1.0 OR 3.0% SENSITIZATION AND 10% CHALLENGE.
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