National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10005-e

Testing Status of 2-Amino-4-nitrophenol - 10005-E

 

CASRN: 99-57-0

Formula: C6-H6-N2-O3

Synonyms/Common Names

  • C.I. 76530

Known Uses

Intermediate for dyes; in hair dyes

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55958)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55958)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6.3, 200 MG/ML/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55958)  Report Complete 
    • TR-339 (NIH Number: 88-2595)  (Peer Review Approval 07/14/1987A )
      Toxicology and Carcinogenesis Studies of 2-Amino-4-Nitrophenol (CASRN 99-57-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 125, 250 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (483411)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (705388)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (A12647)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A57599)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (138517)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 
  • Salmonella  (870165)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 
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