National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10007-l

Testing Status of Cinnamaldehyde - 10007-L

 

CASRN: 104-55-2

Related: TRANS-CINNAMALDEHYDE (14371-10-9)

Formula: C9-H8-O

Synonyms/Common Names

  • Cinnamic aldehyde
  • 3-Phenyl-2-propenal

Known Uses

Cinnamon flavor agent. Perfume industry. Filtering agent. chief ingredient of oil of cinnamon. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C56111)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 321, 642, 1285, 2570, OR 5140 MG/KG.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0708)  Completed 
    • Citation: Yuan J, Bucher JR, Goehl TJ, Dieter MP, Jameson CW. Quantitation of cinnamaldehyde and cinnamic acid in blood by HPLC. J Anal Toxicol. 1992 Nov-Dec;16(6):359-62.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0710)  Completed 
    • Citation: Yuan J, Dieter MP, Bucher JR, Jameson CW. Application of microencapsulation for toxicology studies. III. Bioavailability of microencapsulated cinnamaldehyde. Fundam Appl Toxicol. 1993 Jan;20(1):83-7.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 50, 250, & 500 mg/kg.
  • Toxicokinetic Study (Dosed-Feed)  (S0709)  Completed 
    • Citation: Yuan JH, Dieter MP, Bucher JR, Jameson CW. Toxicokinetics of cinnamaldehyde in F344 rats. Food Chem Toxicol. 1992 Dec;30(12):997-1004.Pubmed Abstract
    • Male and Female Rats: F344/N

Genetic Toxicology

  • Micronucleus  (A60799)  Completed 
    • Mice: B6C3F1
    • Male Negative 

Organ Systems Toxicity

  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0054A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 1200 MG/KG BODY WEIGHT.
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