Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Toluene 10009-V

 

CASRN: 108-88-3

Formula: C7-H8

Synonyms/Common Names

  • Methylbenzene (9CI)

Short-Term Toxicity

  • 13 weeks (Inhalation)  (C07272B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: GAV:(C07272A) 0, 312, 625, 1250, 2500, 5000 MG/KG; INHAL:0, 100, 625, 1250, 2500, 3000 PPM/10 PER GROUP.
  • 13-Week (Gavage)  (C07272C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 312, 5000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 15 months & 2 years (Inhalation)  (C07272B)  Completed 
    • TR-371 (NIH Number: 90-2826)  (Peer Review Approval 03/13/1989A )
      Toxicology and Carcinogenesis Studies of Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 600, 1200, M: 0, 120, 600, 1200 PPM/60 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0615)  Completed 
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: Rats: 45, 1.9, 1.5, 0.05, and 0.005 mg/kg Mice: 50, 5, 0.5, and 0.005 mg/kg.
  • Metabolism  (S0714)  Completed 
    • Citation: Chapman DE, Moore TJ, Michener SR, Powis G. Metabolism and covalent binding of [14C]toluene by human and rat liver microsomal fractions and liver slices. Drug Metab Dispos. 1990 Nov-Dec;18(6):929-36.Pubmed Abstract
    • Male Rats: F344/N; Human (Cell Lines)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (638654)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (434629)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Equivocal 
  • Salmonella  (132615)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Inhalation)  (NTA94013)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male Rats: F344/N
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0063A)  Completed 
    • Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
    • Female Mice: Swiss
    • Dose: 2350 MG/KG BD WT.
  • 6 to 13 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0063B)  Completed 
    • Female Mice: Swiss
    • Dose: 3000 MG/KG/D.