Testing Status of Carbon disulfide 10014-H

 

CASRN: 75-15-0

Formula: C-S2

Synonyms/Common Names

  • Carbon bisulfide

Known Uses

Manufacture of rayon, carbon tetrachloride, cellophane and other regenerated cellulosics, rubber chemicals and soil disinfectants; solvent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13-Week (Inhalation)  (C04591B)  Completed 
    • Rats: Not Available
  • 13 weeks (Inhalation)  (C04591C)  Completed 
    • Rats: F344/N
    • Dose: RATS ONLY: 0, 50, 500, OR 800 PPM.
  • 20 weeks (Inhalation)  (C04591D)  Completed 
    • Mice: C57BL/6
    • Dose: MICE ONLY: 0, 50, 500, OR 800 PPM.

Special Studies

  • (K00285)  Completed 
    • (K00466)  Completed 
      • (K00571)  Completed 
        • Toxicokinetic Study (Inhalation; Intravenous)  (S0559)  Completed 
          • Citation: Moorman MP, Sills RC, Collins BJ, Morgan DL. Carbon disulfide neurotoxicity in rats: II. Toxicokinetics. Neurotoxicology. 1998 Feb;19(1):89-97.Pubmed Abstract
          • Male Rats: F344/N; Female Rats: F344/N

        Genetic Toxicology

        • In Vitro Cytogenetics (CA/SCE)  (635693)  Completed 
          • Sister Chromatid Exchange Positive 
          • Chromosome Aberrations Negative 
        • Salmonella  (105153)  Completed 
          • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
          •  Negative 
        • Salmonella  (436781)  Completed 
          • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
          •  Negative 

        Organ Systems Toxicity

        • Neurotoxicology Assessment (Inhalation)  (NTA94007)  Completed 
          • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
          • Male Rats: F344/N
        • 0 to 21 GD, or 7 to 21 GD, or 7 hour/day, 5 day/week for 3 weeks plus 0 to 21 GD or 7 hour/day, 5 days/week for 3 weeks plus 7 to 21 GD Conventional Teratology (Inhalation)  (T0023A)  Completed 
          • Citation: Teratogenic-Mutagenic Risk of Workplace Contaminants: Trichloroethylene, Perchloroethylene, Carbon Disulfide
          • Female Rabbit: New Zealand White
          • Dose: 20, 40 ppm 7 hr/day.
        • 0 to 18 GD, or 6 to 18 GD, or 7 hour/day 5 day/week for 3 weeks plus 0 to 18 GD, or 7 hour/day 5 day/week for 3 weeks plus 6 to 18 GD Conventional Teratology (Inhalation)  (T0023B)  Completed 
          • Citation: Teratogenic-Mutagenic Risk of Workplace Contaminants: Trichloroethylene, Perchloroethylene, Carbon Disulfide
          • Female Rats: Sprague Dawley
          • Dose: 20, 40 ppm 7 hr/day.
        • 6 to 15 GD Conventional Teratology (Gavage)  (TER84053)  Completed 
          • Citation: Final Report - Teratologic Evaluation of Carbon Disulfide Administered to CD Rats on Gestational Days 6 through 15
          • Female Rats: Sprague Dawley
          • Rats Maternal Positive 
          • Rats Fetal Positive 
          • Dose: 0, 100, 200, 400, 600 MG/KG/DAY.
        • 6 to 19 GD Conventional Teratology (Gavage)  (TER84054)  Completed 
          • Citation: Final Report - Teratologic Evaluation of Carbon Disulfide Administered to New Zealand White Rabbits on Gestational Days 6 through 19
          • Female Rabbit: New Zealand White
          • Rabbits Maternal Positive 
          • Rabbits Fetal Positive 
          • Dose: 0, 25, 75, 150 MG/KG/DAY.