Testing Status of 1,8-Cineol 10015-L

 

CASRN: 470-82-6

Formula: C10-H18-O

Synonyms/Common Names

  • 1,8-Cineole
  • Eucalyptol
  • 1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane

Known Uses

In cough syrups and expectorants. In perfumery and flavoring. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Microencapsulation in Feed)  (C56575A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 4 weeks (Gavage)  (C56575B)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (590755)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (246429)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative