National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10016-r

Testing Status of 2,3-Dibromo-1-propanol - 10016-R

 

CASRN: 96-13-9

Formula: C3-H6-Br2-O

Synonyms/Common Names

  • 2,3-Dibromopropyl alcohol

Known Uses

Chemical intermediate for flame retardants, insecticides and pharmaceuticals.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Topical Application)  (C55436)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Topical Application)  (C55436)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,44,750 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 46 weeks (Topical Application)  (C55436)  Report Complete 
    • TR-400 (NIH Number: 94-2855)  (Peer Review Approval 06/23/1992A )
      Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,188,375, M: 0,88,177 MG/KG/50 PER GROUP.
  • 56 weeks (Topical Application)  (C55436)  Report Complete 
    • TR-400 (NIH Number: 94-2855)  (Peer Review Approval 06/23/1992A )
      Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,188,375, M: 0,88,177 MG/KG/50 PER GROUP.

Special Studies

  • Toxicokinetic Study (Intravenous)  (S0249)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (390611)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (420840)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Mouse Lymphoma  (512622)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (137189)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (075374)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.