Testing Status of Dichlorvos 10017-V

 

CASRN: 62-73-7

Formula: C4-H7-Cl2-O4-P

Synonyms/Common Names

  • DDVP
  • 2,2-Dichloroethenyl phosphoric acid dimethyl ester

Known Uses

Insecticide. Fumigant. Veterinary use for quick knockdown of insects. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00113A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00113A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0, 4000, 12000 PPM/10 PER GROUP.
  • 13-Week (Gavage)  (C00113B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 2, 64, M: 0, 5, 160 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00113A)  Report Complete 
    • TR-010 (NIH Number: 77-810)  (Peer Review Approval 09/00/1976A )
      Bioassay of Dichlorvos for Possible Carcinogenicity (CASRN 62-73-7)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 150, 650 (AVG), M: 0, 650, 1300 (AVG) PPM/50 PER GROUP.
  • 2 years (Gavage)  (C00113B)  Report Complete 
    • TR-342 (NIH Number: 89-2598)  (Peer Review Approval 07/14/1987A )
      Toxicology and Carcinogenesis Studies of Dichlorvos (CASRN 62-73-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 4, 8, MM: 0, 10, 20, FM: 0, 20, 40 MG/KG/50 PER GROUP.

Special Studies

  • Cell Proliferation (Dosed-Feed)  (S0223)  Completed 
    • Citation: Cunningham ML, Elwell MR, Matthews HB. Relationship of carcinogenicity and cellular proliferation induced by mutagenic noncarcinogens vs carcinogens. III. Organophosphate pesticides vs tris(2,3-dibromopropyl)phosphate. Fundam Appl Toxicol. 1994 Oct;23(3):363-9.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: UP TO 400 PPM.
  • C. elegans  (S0901)  Completed 
    • C. elegans
    • Dose: feed (0, .01, .021, .046, .1, .21, .46, 1, 2.1, 4.6, 10, 21) uM 5/17/07; growth (0, .1, .16..25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10) uM 6/19/06; repro (0, .1, .16, .25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10) uM 6/14/06.

Genetic Toxicology

  • Chromosome Aberrations  (755734)  Completed 
    • Mice
    •  Negative 
  • Chromosome Aberrations  (918411)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (584062)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (282595)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (A02017)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A26112)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (632911)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Sister Chromatid Exchanges  (755734)  Completed 
    • Mice
    • Sister Chromatid  Negative 
  • Sister Chromatid Exchanges  (918411)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)