National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10018-y

Testing Status of Ethylbenzene - 10018-Y

 

CASRN: 100-41-4

Formula: C8-H10

Synonyms/Common Names

  • Benzene, ethyl-(8CI) (9CI)
  • EB
  • Phenylethane

Known Uses

Manufacture of synthetic rubber. Solvent. Fuel additive. Chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 13 weeks (Inhalation)  (C56393)  Report Complete 
    • TOX-10 (NIH Number: 92-3129)
      Toxicity Studies of Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0, 100, 250, 500, 750, 1000PPM.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C56393B)  Report Complete 
    • TR-466 (NIH Number: 99-3956)  (Peer Review Approval 12/11/1996A )
      Toxicology and Carcinogenesis Studies of Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Some Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 0, 75, 250, OR 750 PPM (50/SEX/SPECIES/GROUP).

Special Studies

  • Toxicokinetic Study (Dosed-Feed)  (S0636)  Completed 
    • Citation: Ethylbenzene Two-Week Repeated-Dose Inhalation Toxicokinetic Study Report. December 1998. Revised January 2000
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (228892)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (746837)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Micronucleus  (A97698)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (450636)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • 5 consecutive days Dominant Lethal (Intraperitoneal Injection)  (T0048C)  Completed 
    • Male Rats: Sprague Dawley
    • Dose: 850 mg/kg for 5 consecutive days.
  • 1 to 24 GD Conventional Teratology (Inhalation)  (T0048A)  Completed 
    • Citation: Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol
    • Female Rabbit: New Zealand White
    • Dose: 100 or 960 ppm.
  • Pregestation: 7 hr/day, 5 day/wk for 3 wks. Gestation: 7 hr/day , 1 to 19 GD Conventional Teratology (Inhalation)  (T0048B)  Completed 
    • Citation: Teratologic Assessment of Ethylbenzene and 2-Ethoxyethanol
    • Female Rats: Wistar
    • Dose: Pregestation: 95, 960 ppm. Gestation: 95, 985 ppm..
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.