National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10019-d

Testing Status of Chloroethane - 10019-D

 

CASRN: 75-00-3

Formula: C2-H5-Cl

Synonyms/Common Names

  • Ethane, chloro-
  • Ethyl chloride

Known Uses

This compound is used in the manufacture of tetraethyl lead, ethyl cellulose, sulfanol and trional; as an anesthetic; in organic synthesis; as an alkylating agent; in refrigeration; as an analytical reagent; as a solvent for phosphorous , sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs (Radian H&S, 1991). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C06224)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C06224)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 2500, 19000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C06224)  Report Complete 
    • TR-346 (NIH Number: 90-2801)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Inadequate Study 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 15000 PPM/50 PER GROUP.

Genetic Toxicology

  • Micronucleus  (A92751)  Completed 
    • Mice: B6C3F1
    • Male Not a Valid Test 
  • Salmonella  (306504)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
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