Testing Status of Ethylene oxide 10020-A

 

CASRN: 75-21-8

Formula: C2-H4-O

Synonyms/Common Names

  • Oxirane (9CI)

Known Uses

Accelerates ripening in fruit and maturing of tobacco leaves. Fungistat. Rocket propellant. Fumigant for foodstuffs and textiles. Organic synthesis. Sterilize surgical instruments. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C50088)  Completed 
    • Mice: B6C3F1
  • 13-Week (Inhalation)  (C50088)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 50, 100, 200, 400, 600 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C50088)  Report Complete 
    • TR-326 (NIH Number: 88-2582)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: 0, 50, 100 PPM/50 PER GROUP.

Organ Systems Toxicity

  • Biochemical Specific Locus (Inhalation)  (BSLM38)  Completed 
    • Citation: Lewis, S.E., Barnett, L.B., Felton, C., Johnson, F.M., Skow, L.C., Cacheiro, N., and Shelby, M.D. Dominant visible and electrophoretically expressed mutations induced in male mice exposed to ethylene oxide by inhalation. Environ. Mutagen. 8:867-872 (1986).
    • Male Mice: DBA/2J
    • Mice Male Positive 
  • Dominant Lethal (Female) (Dosed-Feed)  (DLF023)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L. Concentration-response curves for ethylene oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:126-131 (1990).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Male)  (DLM022)  Completed 
    • Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Braden, P.W. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutation Res. 176:269-274 (1987).
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Heritable Translocation Test (Dosed-Feed)  (HTM32)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L. Concentration-response curves for ethylene oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16:126-131 (1990).
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Morphological Specific Locus (Dosed-Feed)  (MSLM42)  Completed 
    • Citation: Russell, L.B., Cummings, R.B., and Hunsicker, P.R. Specific-Locus mutation rates in the mouse following inhalation of ethylene oxide and application of the results estimation of human genetic risk. Mutation Res. 129:381-388 (1984).
    • Male Mice: 101 X C3H
    • Mice Male Negative 
  • Preimplantation Zygote Effects (Dosed-Feed)  (PZEF48)  Completed 
    • Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Braden, P.W. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutation Res. 176:269-274 (1987).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • 5 consecutive days Continuous Breeding (Legacy) (Inhalation)  (T0024C)  Completed 
    • Male Mice: C3H
    • Dose: 100 ppm 7 hr/day for 5 days.
  • 4 to 6 GD, 6 to 8 GD, 8 to 10 GD, 10 to 12 GD Conventional Teratology (Intravenous)  (T0024A)  Completed 
    • Citation: Teratologic Evaluation of Ethylene Oxide
    • Female Mice: Swiss
    • Dose: 75, 150 mg/kg/day.
  • 8 to 16 GD or 1 to 16 GD or 3 weeks before breeding plus 1 to 16 GD Conventional Teratology (Inhalation)  (T0024D)  Completed 
    • Citation: Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate
    • Female Rats: Sprague Dawley
    • Dose: 150 ppm 7 hr/day.
  • 7 to 19 GD or 1 to 19 GD Conventional Teratology (Inhalation)  (T0024E)  Completed 
    • Citation: Teratogenic Study of Ethylene and Propylene Oxide and n-Butyl Acetate
    • Female Rabbit: New Zealand White
    • Dose: 150 ppm 7 hr/day.
  • 6 to 14 GD and 6 to 9 GD Conventional Teratology (Intravenous)  (TER82078)  Completed 
    • Citation: Teratologic Evaluation of Ethylene Oxide in New Zealand White Rabbits
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: PART A: GD 6-14, WATER VEHICLE AT 0, 9, 18, & 36 MG/KG. PART B: GD 6-9, 5% DEXTROSE VEHICLE AT 0, 18, & 36 MG/KG..
  • Total Reproductive Capacity (Gavage)  (TRC98017)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Positive