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Testing Status of 8-Methoxypsoralen 10023-L

 

CASRN: 298-81-7

Formula: C12-H8-O4

Synonyms/Common Names

  • 9-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one
  • 8-MOP

Known Uses

Used in PUVA therapy for treatment of psoriasis & vitiligo, in tanning preparations (primarily production in Europe)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55903)  Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C55903)  Completed 
    • Rats: F344/N
    • Dose: 0, 25, 400 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55903)  Completed 
    • TR-359 (NIH Number: 89-2814)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats No Evidence 
    • Dose: R: 0, 37.5, 75 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (501444)  Completed 
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (421568)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (158726)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Salmonella  (773087)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 6 to 9 GD Conventional Teratology (Gavage)  (TER91016)  Completed 
    • Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in New Zealand White Rabbits
    • Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in New Zealand White Rabbits
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Negative 
    • Dose: 0, 40, 80, 105 MG/KG.
  • 6 to 16 GD Conventional Teratology (Gavage)  (TER91017)  Completed 
    • Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in Sprague-Dawley (CD) Rats
    • Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 20, 80, 120, 160 MG/KG/DAY.
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90007)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 20, 100, 200, 400, 600 MG/KG.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP90008)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, 10, 50, 80, 160 MG/KG.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP91017)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, 10, 50, 80, 105 MG/KG.