National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10024-r

Testing Status of Pentachloroanisole - 10024-R

 

CASRN: 1825-21-4

Formula: C7-H3-Cl5-O

Synonyms/Common Names

  • Pentachloromethoxybenzene (9CI)

Known Uses

Degradation product of other chemicals such as pentachlorophenol and pentachloronitrobenzene

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C56520)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 100, 125, 150, 175, or 200 mg/kg M: 0, 100, 175, 250, 325, or 400 mg/kg.
  • 13 weeks (Gavage)  (C56520)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 40, 80, 120, 140, or 180 mg/kg; 10/sex/group.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56520)  Report Complete 
    • TR-414 (NIH Number: 93-3145)  (Peer Review Approval 11/21/1991A )
      Toxicology and Carcinogenesis Studies of Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 
    • Dose: MR: 0, 10, 20, or 40 FR&M: 0, 20, or 40 mg/kg.

Special Studies

  • Toxicokinetic Study (Intravenous)  (S0361)  Completed 
    • Citation: Yuan JH, Goehl TJ, Murrill E, Moore R, Clark J, Hong L, Irwin R. Toxicokinetics of pentachloroanisole in F344 rats and B6C3F1 mice. Xenobiotica. 1993 Apr;23(4):427-38.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (259382)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (644226)  Completed 
    • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
    • Mice
    •  Positive 
  • Salmonella  (596505)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (T0120)  Completed 
    • Female Mice: Swiss
    • Dose: 0, 40, 80, 100, 160 MG/KG/DAY.
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