National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10025-v

Testing Status of Tetranitromethane - 10025-V

 

CASRN: 509-14-8

Formula: C-N4-O8

Synonyms/Common Names

  • TNM

Known Uses

Rocket propellants; additive to diesel fuel; explosive; reagent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C55947)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C55947)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,.1,10 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C55947)  Report Complete 
    • TR-386 (NIH Number: 90-2841)  (Peer Review Approval 11/20/1989A )
      Toxicology and Carcinogenesis Studies of Tetranitromethane (CASRN 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,2,5, M: 0,0.5,2 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (247313)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (631374)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 
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