National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10026-y

Testing Status of Trimellitic anhydride - 10026-Y

 

CASRN: 552-30-7

Formula: C9-H4-O5

Synonyms/Common Names

  • 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid (9CI)

Known Uses

In preparation of resins, adhesives, polymers, dyes, printing inks. Plasticizer. High-temperature plastics. Wire insulation gaskets. Automotive upholstery.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C56633A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Gavage)  (C56633B)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Genetic Toxicology

  • Salmonella  (931027)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0113A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 550 MG/KG BD WT.
  • 6 to 13 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0113B)  Completed 
    • Female Mice: Swiss
    • Dose: 800 MG/KG/D.
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