National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10028-g

Testing Status of Chlorendic acid - 10028-G

 

CASRN: 115-28-6

Formula: C9-H4-Cl6-O4

Synonyms/Common Names

  • 1,4,5,6,7,7-Hexachlorobicyclo(2.2.1)-5-heptene-2,3-dicarboxylic acid

Known Uses

Flame retardant, intermediate for plasticizers, hardening agent (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55072)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55072)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 620, 10000, M: 0, 1250, 20000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C55072)  Report Complete 
    • TR-304 (NIH Number: 87-2560)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 620, 1250 PPM/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0074)  Completed 
    • Citation: Decad GM, Fields MT. Disposition and excretion of chlorendic acid in Fischer 344 rats. J Toxicol Environ Health. 1982 May-Jun;9(5-6):911-20.Pubmed Abstract
    • Male Rats
    • Dose: PO: 3 MG/KG IV: 3 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (179071)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • Drosophila  (960855)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (197818)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Salmonella  (995372)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.