National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10029-k

Testing Status of Hydrochlorothiazide - 10029-K

 

CASRN: 58-93-5

Formula: C7-H8-Cl-N3-O4-S2

Synonyms/Common Names

  • 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Known Uses

Diuretic for hypertension treatment and in veterinary medicine. Adjunct for treatment of edema.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55925)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55925)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 108 weeks (Dosed-Feed)  (C55925)  Report Complete 
    • TR-357 (NIH Number: 89-2812)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,250,500,2000 PPM/60 PER GROUP, M: 0,2500,5000 PPM/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C55925)  Report Complete 
    • TR-357 (NIH Number: 89-2812)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,250,500,2000 PPM/60 PER GROUP, M: 0,2500,5000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (949863)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (044099)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (573028)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Salmonella  (715548)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (TER84084)  Completed 
    • Citation: Final Report - Teratologic Evaludation of Hydrochlorothiazide Administered to CD Rats on Gestational Days 6 through 15
    • Female Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Negative 
    • Dose: 100, 300, 1000 MG/KG/DAY.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER84085)  Completed 
    • Citation: Final Report - Teratologic Evaluation of Hydrochlorothiazide Administered to CD-1 Mice on Gestational Days 6 through 15
    • Female Mice: Swiss
    • Mice Maternal Negative 
    • Mice Fetal Negative 
    • Dose: 300, 1000, 3000 MG/KG/DAY.
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