National Toxicology Program

National Toxicology Program

Testing Status of Vinyl toluene - 10032-R


CASRN: 25013-15-4

Formula: C9-H10

Synonyms/Common Names

  • Ethenylmethylbenzene (9CI)

Known Uses

Preparing polyester resins, modified alkyl resins, and drying oils. In orthopedic cast material.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C56406)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C56406)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 1000, M: 0, 10, 160 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C56406)  Report Complete 
    • TR-375 (NIH Number: 90-2830)  (Peer Review Approval 11/20/1989A )
      Toxicology and Carcinogenesis Studies of Vinyl Toluene (Mixed Isomers) (65%-71% meta-isomer and 32%-35% para-isomer) (CASRN 25013-15-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 100, 300, M: 0, 10, 25 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (390795)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (327329)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (527349)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 5 consecutive days Dominant Lethal (Intraperitoneal Injection)  (T0141)  Completed 
    • Male Rats: Sprague Dawley
    • Dose: 500 mg/kf for 5 cons d.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.