National Toxicology Program

National Toxicology Program

Testing Status of Pentachloronitrobenzene - 10033-V


CASRN: 82-68-8

Formula: C6-Cl5-N-O2

Synonyms/Common Names

  • Batrilex

Known Uses

Fungicide, soil fumigant and seed treatment. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00419A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00419A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0,2150,46400 PPM/5 PER GROUP.
  • 13-Week (Dosed-Feed)  (C00419B)  Completed 
    • Mice: B6C3F1
    • Dose: MM: 0,.125,2.00, FM: 0,.25,4.00 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00419A)  Report Complete 
    • TR-061 (NIH Number: 78-1311)  (Peer Review Approval 01/18/1978A )
      Bioassay of Pentachloronitrobenzene for Possible Carcinogenicity (CASRN 82-68-8)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0,5417,10064 (AVG), FR: 0, 7875, 14635 (AVG), MM: 0, 2606, 5213 (AVG), FM: 0, 4043, 8187 (AVG) PPM/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C00419B)  Report Complete 
    • TR-325 (NIH Number: 87-2581)  (Peer Review Approval 03/26/1986A )
      Toxicology and Carcinogenesis Studies of Pentachloronitrobenzene (CASRN 82-68-8) in B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0,2500,5000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (027750)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (114657)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (303135)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (251113)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.