National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10035-d

Testing Status of Boric acid - 10035-D

 

CASRN: 10043-35-3

Formula: B-H3-O3

Synonyms/Common Names

  • Boracic acid

Known Uses

Weatherproofing wood. Fireproofing fabrics. Printing and dyeing. Astringent. Antiseptic. In cosmetic powders. In manufacture of cements, crockery, glass, leather, carpets, hats and soaps.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C56417)  Completed 
    • Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C56417)  Completed 
    • Mice: B6C3F1
    • Dose: 0,1200,2000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56417)  Report Complete 
    • TR-324 (NIH Number: 88-2580)  (Peer Review Approval 03/26/1986A )
      Toxicology and Carcinogenesis Studies of Boric Acid (CASRN 10043-35-3) in B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0,2500,5000 PPM/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0787)  Completed 
    • Citation: Ku WW, Chapin RE, Moseman RF, Brink RE, Pierce KD, Adams KY. Tissue disposition of boron in male Fischer rats. Toxicol Appl Pharmacol. 1991 Oct;111(1):145-51.Pubmed Abstract
    • Male Rats: F344/N
  • Mechanisms (Dosed-Feed)  (S0788)  Completed 
    • Citation: Ku WW, Chapin RE, Wine RN, Gladen BC. Testicular toxicity of boric acid (BA): relationship of dose to lesion development and recovery in the F344 rat. Reprod Toxicol. 1993 Jul-Aug;7(4):305-19.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (153962)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (621739)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella  (683471)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (789471)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Equivocal 

Organ Systems Toxicity

  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB88034)  Completed 
    • Citation: Reproductive Toxicity of Boric Acid in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: N/A; 0,1000,4500,9000 PPM; 0,4500 PPM; 0,1000 PPM.
  • 10, 14, or 21 days Spermiation Inhibition (Dosed-Feed)  (RACB93162)  Completed 
    • Male Rats: F344/N
    • Dose: </= 9000 PPM.
  • 0 to 20 GD Conventional Teratology (Dosed-Feed)  (TER89027)  Completed 
    • Citation: Final Report on the Developmental Toxicity Evaluation of Boric Acid Administered in Feed to Sprague-Dawley (CD) Rats on Gestational Days 0-20 or 6-15
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, .1, .2, .4, .8%.
  • 1 to 17 GD Conventional Teratology (Dosed-Feed)  (TER89028)  Completed 
    • Citation: Final Report on the Developmental Toxicity Evaluation of Boric Acid Administered in Feed to CD-1 Mice on Gestational Days 0 to 17
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 0.1, 0.2, 0.4%.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER90003)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Boric Acid in New Zealand White Rabbits
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 62.5, 125, 250 MG/KG/DAY.
  • 14 to 17 GD Conventional Teratology (Dosed-Feed)  (TER90123)  Completed 
    • Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 14-17
    • Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 14-17
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 0.8, 1.6, 2.4% AND PAIR FED CONTROL FOR 2.4%.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER93138)  Completed 
    • Citation: CNS Developmental Toxicity of Boric Acid (CASRN 10043-35-3) in Sprague-Dawley CD® Rats Exposed on Gestation Days 6-15. Volume II
    • Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 6-15
    • Citation: Final Report on the CNS Developmental Toxicity of Boric Acid in Sprague-Dawley CD Rats Exposed on Gestation Days 6-15
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, .4, .5, .6, .8% *.
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