National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10037-k

Testing Status of 2,3,7,8-Tetrachlorodibenzofuran - 10037-K

 

CASRN: 51207-31-9

Formula: C12-H4-Cl4-O

Synonyms/Common Names

  • TCDF

Known Uses

No industrial use. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0235)  Completed 
    • Citation: Birnbaum LS, Decad GM, Matthews HB. Disposition and excretion of 2,3,7,8-tetrachlorodibenzofuran in the rat. Toxicol Appl Pharmacol. 1980 Sep 15;55(2):342-52.Pubmed Abstract
    • Male Mice: B6C3F1
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0254)  Completed 
    • Citation: Ioannou YM, Birnbaum LS, Matthews HB. Toxicity and distribution of 2,3,7,8-tetrachlorodibenzofuran in male guinea pigs. J Toxicol Environ Health. 1983 Oct-Dec;12(4-6):541-53.Pubmed Abstract
    • Guinea Pigs
  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0257)  Completed 
    • Citation: Birnbaum LS, Decad GM, Matthews HB, McConnell EE. Fate of 2,3,7,8-tetrachlorodibenzofuran in the monkey. Toxicol Appl Pharmacol. 1981 Feb;57(2):189-96.Pubmed Abstract
    • Monkey
  • Absorption Disposition Metabolism Elimination  (S0429)  Completed 
    • Citation: Decad GM, Birnbaum LS, Matthews HB. Disposition of 2,3,7,8-tetrachlorodibenzofuran in guinea pigs, rats & monkeys. In: Hutzinger O, Frei RW, Merian E, and Pocchiari F, eds. Chlorinated Dioxins & Related Compounds. Impact on the Environment. Pergamon Press; 1982;307-315.
    • Male Rats: F344/N; Male Guinea Pigs; Male Monkey
    • Dose: 14C-TCDF P.O. & IV GUINEA PIG 0.02 UMOLES/KG, F344 RATS 0.1 & 1.0 UMOLES/KG & IV RHESUS MONKEY 0.1 UMOLES/KG.
  • Absorption Disposition Metabolism Elimination  (S0430)  Completed 
    • Citation: King FG, Dedrick RL, Collins JM, Matthews HB, Birnbaum LS. Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species. Toxicol Appl Pharmacol. 1983 Mar 15;67(3):390-400.Pubmed Abstract
    • Rats: F344/N; Mice: B6C3F1; Monkey
  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0439)  Completed 
    • Citation: Decad GM, Birnbaum LS, Matthews HB. Distribution and excretion of 2,3,7,8-tetrachlorodibenzofuran in C57BL/6J and DBA/2J mice. Toxicol Appl Pharmacol. 1981 Jul;59(3):564-73.Pubmed Abstract
    • Male Mice: C57BL/6; Male Mice
  • Absorption Disposition Metabolism Elimination  (S0489)  Completed 
    • Citation: Decad GM, Birnbaum LS, Matthews HB. 2,3,7,8-Tetrachlorodibenzofuran tissue distribution and excretion in guinea pig. Toxicol Appl Pharmacol. 1981 Feb;57(2):231-40.Pubmed Abstract
    • Guinea Pigs
  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0686)  Completed 
    • Citation: Brewster DW, Banks YB, Clark AM, Birnbaum LS. Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans. Toxicol Appl Pharmacol. 1989 Jan;97(1):156-66.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0.1, 0.5, 1.0 µmol/kg.
  • Metabolism (in-vitro)  (S0233)  Completed 
    • Citation: Burka L, Mcgown SR, Tomer KB. Identification of the biliary metabolites of 2,3,7,8-tetrachlorodibenzofuran in the rat. Chemosphere.1990; 21(10-11):1231-1242.
    • Male Rats: F344/N
    • Dose: 270 UG/KG (0.92 UCI/KG).
  • Other  (S0432)  Completed 
    • Citation: Burka LT, Overstreet D. Synthesis of possible metabolites of 2,3,7,8-tetrachlorodibenzofuran. J. Agric. Food Chem. 1989; 37:1528-1532
    • Rats

Organ Systems Toxicity

  • Single dose Immunotoxicity (Gavage)  (I10037)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 3, 9, 15, 30 and 90 ug/kg.

Toxicogenomics

  • Microarray Analysis  (T10037)  Completed 
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