National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10039-t

Testing Status of N,N-Dimethylaniline - 10039-T

 

CASRN: 121-69-7

Formula: C8-H11-N

Synonyms/Common Names

  • N,N-Dimethylbenzenamine

Known Uses

Dyes, intermediates; solvent; manufacture of vanillin; stabilizer (acid receptor). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56428)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56428)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 36.25, 500, M: 0, 62.5, 500 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56428)  Report Complete 
    • TR-360 (NIH Number: 90-2815)  (Peer Review Approval 03/13/1989A )
      Toxicology and Carcinogenesis Studies of N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0, 3, 30, M: 0, 15, 30 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (609568)  Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (365373)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (840758)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0092)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 365 MG/KG BODY WT..
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