National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10042-y

Testing Status of Ethanol - 10042-Y

 

CASRN: 64-17-5

Formula: C2-H6-O

Synonyms/Common Names

  • Ethyl alcohol

Known Uses

Solvent. In alcoholic beverages and manufacture of denatured alcohols. In gasohol. Anti-freeze agent. Chemical intermediate. In synthetic rubber, coatings, cosmetics, disinfectants, and pharmaceuticals. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C00602E)  Report Complete 
    • TR-510 (NIH Number: 04-4444)  (Peer Review Approval 09/05/2002A )
      Toxicology and Carcinogenesis Studies of Urethane + Ethanol (CASRNs 51-79-6 & 64-17-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Carcinogenesis Results
      • Male Mice Inadequate Study 
      • Female Mice Inadequate Study 
    • Dose: 0, 10, 30, 0R 90 PPM.

Special Studies

  • C. elegans  (S0927)  Completed 
    • C. elegans
    • Dose: feed (0, .057, .114, .228, .342, .467, .570, .684, .798, .912, 1.03, 1.14) M; 10/30/06 repro (0, .5, .63, .79, 1.0, 1.3, 1.6, 2.0, 2.5, 3.2, 4.0, 5.0)%; 12/04/06growth (0.222, .274, .342, .427, .547, .684, .855, 1.08, 1.35, 1.71, 2.22) M; 06/27/07.

Genetic Toxicology

  • Salmonella  (427021)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84095)  Completed 
    • Citation: Ethanol: Reproduction and Fertility Assessment In CD-1 Mice When Administered In the Drinking Water
    • Male and Female Mice: Swiss
    • Dose: N/A; 5, 10, 15%; N/A; N/A.
  • 1 to 19 GD (sperm = 0 days) Conventional Teratology (Inhalation)  (T0014B)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 10000, 16000 AND 20000 PPM.
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