National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10046-p

Testing Status of Naphthalene - 10046-P

 

CASRN: 91-20-3

Formula: C10-H8

Synonyms/Common Names

  • Napthene

Known Uses

Chemical intermediate, insecticides, repellants, antiseptic, vermicide, synthetic resins; in various commercial moth repellants and toilet bowl cleaners; topically in veterinary medicine. Prepared from coal tar. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C52904B)  Report Complete 
    • TR-410 (NIH Number: 92-3141)  (Peer Review Approval 03/11/1991A )
      Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in B6C3F1 Mice (Inhalation Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: 0,10 (75 mice/sex/group),30 (150 mice/sex/group) PPM.
  • 2 years (Inhalation)  (C52904C)  Report Complete 
    • TR-500 (NIH Number: 01-4434)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in F344/N Rats (Inhalation Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: R: 0, 10, 30, OR 60 PPM; 58/SEX/GROUP.

Special Studies

  • Toxicokinetic Study (Intravenous)  (S0571)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: SINGLE ADMINISTRATION IV RATS 3, 10, & 30 MG/KG; Mice 1, 3, and 10 mg/kg..
  • Toxicokinetic Study (Inhalation)  (S0606)  Completed 
    • Male and Female Rats: F344/N
    • Dose: Rats: 10, 30, 60 ppm; 58/sex/group.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (040612)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (471098)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0038)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 300 MG/KG BODY WT..
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER91006)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Naphthalene in Sprague-Dawley (CD) Rats
    • Rats: Sprague Dawley
    • Rats Maternal Inadequate 
    • Rats Fetal Inadequate 
    • Dose: 0, 50, 150, 450 MG/KG/DAY.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER91021)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Napthalene in New Zealand White Rabbits
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Negative 
    • Rabbits Fetal Negative 
    • Dose: 0, 20, 80, 120 MG/KG/DAY.
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90014)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 100, 400, 500, 600, OR 800 MG/KG.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP90015)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, 75, 150, 300, OR 500 MG/KG.
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