Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Naphthalene 10046-P

 

CASRN: 91-20-3

Formula: C10-H8

Synonyms/Common Names

  • Napthene

Known Uses

Chemical intermediate, insecticides, repellants, antiseptic, vermicide, synthetic resins; in various commercial moth repellants and toilet bowl cleaners; topically in veterinary medicine. Prepared from coal tar. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C52904B)  Completed 
    • TR-410 (NIH Number: 92-3141)  (Peer Review Approval 03/11/1991A )
      Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in B6C3F1 Mice (Inhalation Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: 0, 10 (75 mice/sex/group), 30 (150 mice/sex/group) PPM.
  • 2 years (Inhalation)  (C52904C)  Completed 
    • TR-500 (NIH Number: 01-4434)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in F344/N Rats (Inhalation Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: R: 0, 10, 30, OR 60 PPM; 58/SEX/GROUP.

Special Studies

  • Toxicokinetic Study (Intravenous)  (S0571)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: SINGLE ADMINISTRATION IV RATS 3, 10, & 30 MG/KG; Mice 1, 3, and 10 mg/kg..
  • Toxicokinetic Study (Inhalation)  (S0606)  Completed 
    • Male and Female Rats: F344/N
    • Dose: Rats: 10, 30, 60 ppm; 58/sex/group.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (040612)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (471098)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0038)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 300 MG/KG BODY WT..
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER91006)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Naphthalene in Sprague-Dawley (CD) Rats
    • Rats: Sprague Dawley
    • Rats Maternal Inadequate 
    • Rats Fetal Inadequate 
    • Dose: 0, 50, 150, 450 MG/KG/DAY.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER91021)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Napthalene in New Zealand White Rabbits
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Negative 
    • Rabbits Fetal Negative 
    • Dose: 0, 20, 80, 120 MG/KG/DAY.
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90014)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 100, 400, 500, 600, OR 800 MG/KG.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP90015)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, 75, 150, 300, OR 500 MG/KG.