National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10047-t

Testing Status of Nitrofurazone - 10047-T

 

CASRN: 59-87-0

Formula: C6-H6-N4-O4

Synonyms/Common Names

  • 2((5-Nitro-2-furanyl)methylene)hydrazinecarboxamide

Known Uses

Antibacterial agent, sensitizer and food additive, experimental carcinogen

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C56064)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 7 weeks (Dosed-Feed)  (C95005)  Completed 
    • Mice: B6C3F1
    • Dose: FEMALE MICE ONLY: 0 OR 310 PPM.
  • 13-Week (Dosed-Feed)  (C56064)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56064)  Report Complete 
    • TR-337 (NIH Number: 88-2593)  (Peer Review Approval 07/14/1987A )
      Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,310,620, M: 0,150,310 PPM/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C95005)  Completed 
    • Mice: B6C3F1
    • Dose: FEMALE MICE ONLY: 0 OR 310 PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (356548)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (267199)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (A59017)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (364720)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 

Organ Systems Toxicity

  • Immunotoxicity (Gavage)  (IMM90011)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Immunotoxicity of Nitrofurazone in Female B6C3F1 Mice
    • Female Mice: B6C3F1
    • Mice Female Negative 
  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB89020)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Nitrofurazone in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0,100,200,400,600,900 PPM; 0,100,375,750 PPM; 0,750 PPM; 0,100,375 PPM.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0012A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 100 MG/KG BODY WT.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER85092)  Completed 
    • Citation: Teratologic Evaluation of Nitrofurazone Administered to CD-1 Mice on Gestational Days 6 through 15
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 0.0038, 0.0075, 0.025, 0.050%.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER87093)  Completed 
    • Citation: Teratologic Evaluation of Nitrofurazone Administered to New Zealand White Rabbits on Gestational Days 6-19
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 5, 10, 15, 20 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.