Testing Status of Rhodamine 6G 10052-G

 

CASRN: 989-38-8

Formula: C28-H31-N2-O3.Cl

Synonyms/Common Names

  • Basic Red 1
  • C.I. Basic Red 1
  • 2-(6-(Ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl)benzoic acid ethyl ester monohydrochloride (9CI)

Known Uses

Dye for silk, cotton, wool, leather, plastic, paper and bast fiber. Tracing agent in water pollution studies.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C56122)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C56122)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, .012, .2, M: 0, .05, .8 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56122)  Report Complete 
    • TR-364 (NIH Number: 89-2819)  (Peer Review Approval 10/04/1988A )
      Toxicology and Carcinogenesis Studies of Rhodamine 6G (C.I. Basic Red 1) (CASRN 989-38-8) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 120, 250, FM: 0, 500, 1000, MM: 0, 1000, 2000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (199566)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (039603)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (666391)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative