Testing Status of Sulfamethazine 10056-X

 

CASRN: 57-68-1

Formula: C12-H14-N4-O2-S

Synonyms/Common Names

  • 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide (9CI)

Known Uses

Veterinary medicine as an antimicrobial, antibacterial and coccidiostat.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C56600B)  Completed 
    • NR-418
      Chronic Toxicity and Carcinogenesis Study of Sulfamethazine in B6C3F1 Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C56600)  Completed 
    • NR-420
      Chronic Toxicity and Carcinogenesis Study on Sulfamethazine in Fischer 344 Rats (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Rats: F344/N

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56600B)  Report Complete 
    • NR-418  (Peer Review Approval NA)
      Chronic Toxicity and Carcinogenesis Study of Sulfamethazine in B6C3F1 Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Mice: B6C3F1
    • Dose: M: 0, 300, 600, 1200, 2400, 4800 PPM.
  • 2 years (Dosed-Feed)  (C56600)  Report Complete 
    • NR-420  (Peer Review Approval NA)
      Chronic Toxicity and Carcinogenesis Study on Sulfamethazine in Fischer 344 Rats (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Rats: F344/N
    • Dose: R: 0, 10, 40, 600, 1200, 2400 PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (930871)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (768024)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB82108)  Completed 
    • Citation: Final Report - Sulfamethazine: Reproduction and Fertility Assessment in CD-1 Mice When Administered Via the Diet
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .25, .5, 1%; 0, 1%; N/A.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER81108)  Completed 
    • Citation: Teratologic Evaluation of Sulfamethazine in CD Rats
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 545, 685, 865 MG/KG/DAY.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER81109)  Completed 
    • Citation: Teratologic Evaluation of Sulfamethazine in New Zealand White Rabbits
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 600, 1200, 1500, 1800 MG/KG/DAY.
  • 20 GD Conventional Teratology (Dosed-Feed)  (TER84001)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 0, 600, 1200, OR 2400 PPM.
  • single exposure Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98050)  Completed 
    • Female Mice: (SEC/E X C57BL/E)F1
    • Dose: 775 MG/KG.