Testing Status of Octyl salicylate 10056

 

CASRN: 118-60-5

Formula: C15-H22-O3

Synonyms/Common Names

  • 2-Ethylhexyl salicylate
  • Octisalate
  • Octyl Salate

Known Uses

an organic compound used as an ingredient in sunscreens and cosmetics to absorb UVB (ultraviolet) rays from the sun. It is an ester formed by the condensation of a salicylic acid with 2-ethylhexanol. It is a colorless oily liquid with a slight floral odor.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • 3 days Hershberger Assay (Gavage)  (K10431B)  Completed 
    • Citation: Final Report: The Hershberger Bioassay; Oxybenzone, Octylmethoxycinnamate, Octylsalate, Octocrylene. 04 January 2012
    • Male Rats: Harlan Sprague-Dawley
    • Dose: 15, 47, or 150 mg/ml.
  • 3 days Uterotrophic Assay (Gavage)  (K10431)  Completed 
    • Citation: Final Report. The Uterotrophic Assay with Oxybenzone, Octylmethoxycinnamate, Octylsalate and Octocrylene. 01 September 2011 Revised: 20 April 2012
    • Female Rats: Sprague Dawley
    • Dose: 5 mL/kg.

in vitro Testing

  • Androgen Receptor Binding Assay  (V10431B)  Completed 
    • Androgen Receptor Binding Assay
  • Estrogen Receptor Binding Assay  (V10431C)  Completed 
    • Estrogen Receptor Binding Assay
  • H295R Steroidogenesis Assay  (V10431)  Completed 
    • H295R Steroidogenesis Assay
  • Androgen Receptor Transactivation Assay  (V10431D)  Completed 
    • Androgen Receptor Transactivation Assay
  • Estrogen Receptor Transactivation Assay  (V10431E)  Completed 
    • Estrogen Receptor Transactivation Assay
  • Human Recombinant Aromatase Assay  (V10431G)  Completed 
    • Human Recombinant Aromatase Assay