National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10057

Testing Status of N-Butylbenzenesulfonamide - 10057

 

CASRN: 3622-84-2

Formula: C10-H15-N-O2-S

Synonyms/Common Names

  • Benzenesulfonic acid butyl amide
  • NBBS

Known Uses

Plasticizer used in polyacetals, polycarbonates, polysulfones, and polyamides (Nylon 11 and Nylon 12).

Chemical Properties

Toxicity Effects (HSDB)

Planned Carcinogenicity/Toxicity

  • 14-Day (Dosed-Feed)  (C10482B)   
    • 13-weekToxicity (C10482B) of N-Butylbenzenesulfonamide (CAS 3622-84-2, TEST ARTICLE #10057) in B6C3F1/N Mice
    • Mice: B6C3F1/N
  • 13-Week (Dosed-Feed)  (C10482B)   
    • Modified One-Generation Study (MOG R# MOG008) in Harlan Sprague Dawley Rats
    • Rats: Harlan Sprague-Dawley

Short-Term Toxicity

  • 14 days (Dosed-Feed)  (C10482)  On Test 
    • Mice: B6C3F1/N
    • Dose: 0, 1250, 2500, 5000, 10000, or 20000 ppm; 5/sex.

Modified One-Generation

  • GD 6 to PND 28 Dose Range Finding (Dosed-Feed)  (MOG10482)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 625, 1250, 2500, 5000 or 10,000 ppm.
  • Developmental Toxicity (Dosed-Feed) Selected (MOG10482B)  
    • Developmental Tox Cohort
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Dosed-Feed) Selected (MOG10482B)  
    • Definitive study (Dam dose start)
    • Rats: Harlan Sprague-Dawley
  • Fertility Assessment (Dosed-Feed) Selected (MOG10482B)  
    • Fertility Cohort
    • Rats: Harlan Sprague-Dawley
  • GD 18 (gestational transfer); PND 4 (lactational transfer) Maternal Transfer (Dosed-Feed) Selected (MOG10482B)  
    • Rats: Harlan Sprague-Dawley
  • 7 days Neurotoxicology Assessment (Dosed-Feed) Selected (MOG10482B)  
    • Neurotoxicity Cohort
    • Rats: Harlan Sprague-Dawley
  • 90 days (up to 35 days for mammary analysis) Subchronic (Dosed-Feed) Selected (MOG10482B)  
    • subchronic with post-weaning mammary gland analysis
    • Rats: Harlan Sprague-Dawley; Rats

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K10482)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
  • Toxicokinetic Study (Gavage; Intravenous)  (K10482B)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N

Genetic Toxicology

  • Salmonella  (G10482)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 - PND 42 Immunotoxicity (Dosed-Feed)  (I10482B)  Assigned 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 500, 1000, or 2000 ppm.
  • 28 days Immunotoxicity (Dosed-Feed)  (I10482)  Assigned 
    • Female Mice: B6C3F1/N
    • Dose: 0, 313, 625, 1250, 2500, or 5000 ppm.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.