National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10059

Testing Status of Ensulizole - 10059

 

CASRN: 27503-81-7

Formula: C13-H10-N2-O3-S

Synonyms/Common Names

  • Phenylbenzimidazole sulfonic acid
  • 2-Phenylbenzimidazole-5-sulfonic acid

Known Uses

Sunscreen

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • 3 days Hershberger Assay (Gavage)  (K10504B)  Completed 
    • Citation: FINAL Report: The Hershberger Bioassay for Ensulizole and Avobenzone 07 November 2012
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 320, 1000.
  • 3 days Uterotrophic Assay (Gavage)  (K10504)  Completed 
    • Citation: FINAL Report: The Uterotrophic Assay with Avobenzone, Ensulizole, Homosalate, and Padimate-O 07 November 2012
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 320, 1000.

in vitro Testing

  • Androgen Receptor Transactivation Assay  (V10504)  Completed 
    • Androgenic Receptor Transactivation Activity [ARTA] in MDA-kb2
  • Estrogen Receptor Binding Assay (Dosed-Feed)  (V10504)  Completed 
    • Estrogen Receptor Binding [ERB] (Rat Uterine Cytosol)
    • Rats: Harlan Sprague-Dawley
  • Androgen Receptor Binding Assay (Gavage)  (V10504)  Completed 
    • Androgen Receptor Binding [ARB] (Rat Prostate Cytosol)
    • Rats: Harlan Sprague-Dawley
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