National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10062-p

Testing Status of Chlorinated paraffins: C23, 43% chlorine - 10062-P

 

CASRN: 108171-27-3

Formula: C24-H43-Cl7

Synonyms/Common Names

  • Cereclor 42
  • Chlorowax 40

Known Uses

Additive in extreme pressure lubricant; flame retardant in rubber, plastic, and paint

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C53543)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C53543)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 109 weeks (Gavage)  (C53543)  Report Complete 
    • TR-305 (NIH Number: 86-2561)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: FR: 0, 100, 300, or 900, MR: 0, 1875, or 3750, M: 0, 2500, or 5000 mg/kg/50 per group.
  • 2 years (Gavage)  (C53543)  Report Complete 
    • TR-305 (NIH Number: 86-2561)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: FR: 0, 100, 300, or 900, MR: 0, 1875, or 3750, M: 0, 2500, or 5000 mg/kg/50 per group.

Genetic Toxicology

  • Mouse Lymphoma  (010900)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Negative 
  • Salmonella  (104775)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.