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Testing Status of Chlorinated paraffins: C12, 60% chlorine 10063-T

 

CASRN: 108171-26-2

Formula: C12-H19-Cl7

Synonyms/Common Names

  • Cereclor 54
  • Chlorowax 500C

Known Uses

Additive for extreme pressure lubricant; flame retardant in rubber, plastic, and paint

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C53587)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C53587)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 313, 5000, M: 0, 469, 7500 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C53587)  Completed 
    • TR-308 (NIH Number: 86-2564)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C12, 60% Chlorine) (CASRN 108171-26-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 312, 625, M: 0, 125, 250 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (132281)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (333321)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (731132)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative