National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10064-x

Testing Status of Cyclohexanone - 10064-X

 

CASRN: 108-94-1

Formula: C6-H10-O

Synonyms/Common Names

  • Pimelin ketone

Known Uses

Solvent for cellulose acetate, nitrocellulose, natural resins, vinyl resins, crude rubber, waxes, fats, shellac & DDT, in production of adipic acid for nylon, in preparation of cyclohexanone resins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13-Week (Dosed-Water)  (C55005)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Water)  (C55005)  Report Complete 
    •   (Peer Review Approval NA) Citation: Lijinsky W, RM Kovatch, Chronic Toxicity Study of Cyclohexanone in Rats and Mice. J Natl Cancer Inst. 1986 Oct;77(4):941-9.
    • Rats: F344/N; Mice: B6C3F1

Genetic Toxicology

  • Mouse Lymphoma  (910786)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella  (486795)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (587795)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
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