Testing Status of 1,2-Epoxybutane 10066-F

 

CASRN: 106-88-7

Formula: C4-H8-O

Synonyms/Common Names

  • Ethyloxirane

Known Uses

For production of butanediols, glycol esters & ethers, preparation of surfactants & gasoline additives, intermediate For polymers, stabilizer (HSDB 1990).

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C55527)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C55527)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 50, 800 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C55527)  Report Complete 
    • TR-329 (NIH Number: 88-2585)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 200, 400, M: 0, 50, 100 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (333393)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (855451)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Mouse Lymphoma  (119097)  Completed 
    • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
    • Mice
    •  Positive 
  • Mouse Lymphoma  (G18246)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Mouse Lymphoma  (G71732)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Micronucleus  (A16097)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (970583)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    •  Positive 
  • Salmonella  (N-9093)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251

Organ Systems Toxicity

  • 5 days/week for 3 weeks before breeding, or 1 to 19 GD, or 3 weeks before breeding plus 1 to 19 GD Conventional Teratology (Inhalation)  (T0056A)  Completed 
    • Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
    • Female Rats: Wistar
    • Dose: 250 or 1000 ppm 7 hr/day.
  • 1 to 24 GD Conventional Teratology (Inhalation)  (T0056B)  Completed 
    • Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
    • Female Rabbit: New Zealand White
    • Dose: 250 or 1000 ppm 7 hr/day.