National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10067-j

Testing Status of Bromoethane (ethyl bromide) - 10067-J

 

CASRN: 74-96-4

Formula: C2-H5-Br

Synonyms/Common Names

  • Bromoethane
  • Ethyl bromide

Known Uses

Chemical intermediate for pharmaceuticals. Ethylating agent in organic synthesis. Refrigerant. Grain and fruit fumigant.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C55481)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C55481)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,100,1600 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C55481)  Report Complete 
    • TR-363 (NIH Number: 90-2818)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CASRN 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0,100,200,400 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (496296)  Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (024373)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (811571)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.