National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10068-n

Testing Status of Furosemide - 10068-N

 

CASRN: 54-31-9

Formula: C12-H11-Cl-N2-O5-S

Synonyms/Common Names

  • 5-(Aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)benzoic acid (9CI)

Known Uses

Diuretic in the treatment of edema and hypertension. Diuretic in veterinary medicine.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55936)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55936)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 107 weeks (Dosed-Feed)  (C55936)  Report Complete 
    • TR-356 (NIH Number: 89-2811)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0,350,700, M: 0,700,1400 PPM/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C55936)  Report Complete 
    • TR-356 (NIH Number: 89-2811)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0,350,700, M: 0,700,1400 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (169457)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (219163)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (912768)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (312303)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (A84903)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.