National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10073-c

Testing Status of 2-Mercaptobenzothiazole - 10073-C

 

CASRN: 149-30-4

Formula: C7-H5-N-S2

Synonyms/Common Names

  • 2(3H)-Benzothiazolethione (9Ci)
  • MBT

Known Uses

Rubber vulcanization accelerator. Salts used as fungicide. Corrosion inhibitor for copper in aqueous systems, cutting oils and petroleum products. Additive in extreme-pressure greases.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56519)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56519)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,.1,10 MG/M3/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56519)  Report Complete 
    • TR-332 (NIH Number: 88-2588)  (Peer Review Approval 03/04/1987A )
      Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: FR: 0,188,375, MR&M: 0,375,750 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (748636)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (997320)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Not Tested 
  • Mouse Lymphoma  (920542)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (A38881)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A62048)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (855075)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Equivocal 
  • Salmonella  (876400)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM90003)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Assessment of Contact Hypersensitivity to 2-Mercaptobenzothiazole in Female B6C3F1 Mice
    • Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
    • Female Mice: B6C3F1
    • Mice Female Positive 
    • Dose: 0, 1, 3, 7.5%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.