Testing Status of Phenol 10076-N

 

CASRN: 108-95-2

Formula: C6-H6-O

Synonyms/Common Names

  • Carbolic acid
  • Hydroxybenzene
  • Phenyl hydroxide

Known Uses

Disinfectant; antiseptic; in resins, organics, and dyes, obtained from coal tar (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Water)  (C50124)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Water)  (C50124)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 100, 10000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Water)  (C50124)  Report Complete 
    • TR-203 (NIH Number: 80-1759)  (Peer Review Approval 02/15/1980A )
      Bioassay of Phenol for Possible Carcinogenicity (CASRN108-95-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 2500, 5000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (170681)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • Chromosome Aberrations  (329606)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (340985)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (726780)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (987728)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Micronucleus  (874983)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (175560)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (759552)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Sister Chromatid Exchanges  (170681)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
  • Sister Chromatid Exchanges  (329606)  Completed 
    • Mice
    • Sister Chromatid  Positive 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (IMM20203)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 5, 20, or 100 mg/L.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER80129)  Completed 
    • Citation: Final Report - Teratologic Evaluation of Phenol in CD-1 Mice
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 70, 140, 280 MG/KG/DAY.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER81104)  Completed 
    • Citation: Teratologic Evaluation of Phenol in CD Rats
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 30, 60, 120 MG/KG/DAY.
  • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98026)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Negative