National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10084-n

Testing Status of 1-Amino-2,4-dibromoanthraquinone - 10084-N

 

CASRN: 81-49-2

Formula: C14-H7-Br2-N-O2

Synonyms/Common Names

  • Alkyl Dimethyl Benzyl Ammonium Chloride (ADBAC).
  • 9,10-Anthracenedione, 1-amino-2,4-dibromo-

Known Uses

In manufacture of dyes.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C55458)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C55458)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 2500, 50000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55458)  Report Complete 
    • TR-383 (NIH Number: 96-2838)  (Peer Review Approval 06/21/1994A )
      Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CASRN 81-49-2) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, .2, .5, 1.0, 2.0, M: 0, 1.0, 2.0 %/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0212)  Completed 
    • Male Rats: F344/N
    • Dose: IV:O.4 MG/KG; PO:2, 23, 118, 814, 1473 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (438792)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (905842)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Salmonella  (685556)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
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