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Testing Status of DL-amphetamine sulfate 10085-S

 

CASRN: 60-13-9

Formula: C9-H13-N.1/2H2-O4-S

Synonyms/Common Names

  • alpha-Methylphenethylamine sulfate, (+-)-

Known Uses

Treatment of narcolepsy and weight problems; for behavior disorders in children

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55710)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55710)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 6.25, 100, M: 0, 25, 400 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55710)  Completed 
    • TR-387 (NIH Number: 91-2842)  (Peer Review Approval 04/25/1990A )
      Toxicology and Carcinogenesis Studies of dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M:0, 20, 100 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (381641)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (561780)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Equivocal