National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10086-w

Testing Status of Azodicarbonamide - 10086-W

 

CASRN: 123-77-3

Formula: C2-H4-N4-O2

Synonyms/Common Names

  • Diazenedicarboxamide

Known Uses

Blowing agent for plastics and rubbers. Maturing agent for flours. Food additive. Chemical foaming agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C55981C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C55981C)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0457)  Completed 
    • Citation: Gerlach RF, Medinsky MA, Hobbs CH, Bice DE, Bechtold WE, Cheng YS, Gillett NA, Birnbaum LS, Mauderly JL. Effect of four-week repeated inhalation exposure to unconjugated azodicarbonamide on specific and non-specific airway sensitivity of the guinea pig. J Appl Toxicol. 1989 Jun;9(3):145-53.Pubmed Abstract
    • Citation: Shopp GM, Cheng YS, Gillett NA, Bechtold WE, Medinsky MA, Hobbs CH, Birnbaum LS, Mauderly JL. Acute inhalation exposure of azodicarbonamide in the guinea pig. Am Ind Hyg Assoc J. 1987 Feb;48(2):127-32.Pubmed Abstract
    • Guinea Pigs
  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0458)  Completed 
    • Male Rats: F344/N
  • Toxicokinetic Study (Inhalation)  (S0058)  Completed 
    • Citation: Mewhinney JA, Ayres PH, Bechtold WE, Dutcher JS, Cheng YS, Bond JA, Medinsky MA, Henderson RF, Birnbaum LS. The fate of inhaled azodicarbonamide in rats. Fundam Appl Toxicol. 1987 Apr;8(3):372-81.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (998177)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • Drosophila  (831837)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (727470)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.