National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10087-a

Testing Status of Benzaldehyde - 10087-A

 

CASRN: 100-52-7

Formula: C7-H6-O

Synonyms/Common Names

  • Benzoic aldehyde

Known Uses

Chemical intermediate for dyes. Solvent for oils, resins, some cellulose ethers, cellulose acetate and nitrate, flavoring compounds, synthetic perfumes. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C56133)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 100, 200, 400, 800, OR 1600 MG/KG M: O, 200, 400, 800, 1600, OR 3200 MG/KG; 5/SEX/SPECIES.
  • 13 weeks (Gavage)  (C56133)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 50, 100, 200, 400, OR 800 MG/KG M: 0, 75, 150, 300, 600, OR 1200 MG/KG; 10/SEX/SPECIES.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56133)  Report Complete 
    • TR-378 (NIH Number: 90-2833)  (Peer Review Approval 06/27/1989A )
      Toxicology and Carcinogenesis Studies of Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R&MM: 0, 200, OR 400 MG/KG FM: 0, 300, OR 600 MG/KG; 50/SEX/SPECIES.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (081912)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (143943)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (895369)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Positive 
  • Salmonella  (489344)  Completed 
    •  Negative 
  • Salmonella  (930477)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.