National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10088-e

Testing Status of Chlorobenzilate - 10088-E

 

CASRN: 510-15-6

Formula: C16-H14-Cl2-O3

Synonyms/Common Names

  • 4-Chloro-alpha-(4-chlorophenyl)-alpha-hydroxybenzeneacetic acid ethyl ester
  • Ethyl 4,4'-dichlorobenzilate

Known Uses

Acaricide for spider mite control (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00408)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00408)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00408)  Report Complete 
    • TR-075 (NIH Number: 78-1325)  (Peer Review Approval 06/29/1978A )
      Bioassay of Chlorobenzilate for Possible Carcinogenicity (CASRN 510-15-6)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Equivocal 
      • Male Mice Positive 
      • Female Mice Positive 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (486951)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (427493)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (159650)  Completed 
    • Mice
    •  Negative 
  • Mouse Lymphoma  (252225)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (313686)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (373410)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (374565)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.