National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10089-h

Testing Status of n-Butyl chloride - 10089-H

 

CASRN: 109-69-3

Formula: C4-H9-Cl

Synonyms/Common Names

  • 1-Chlorobutane

Known Uses

Butylating agent in organic synthesis, solvent, veterinary antihelmintic (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C06155A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C06155A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,30,500 M: 0,60,1000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 108 weeks (Gavage)  (C06155A)  Report Complete 
    • TR-312 (NIH Number: 86-2568)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CASRN 109-69-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,60,120 M: 0,500,1000 MG/KG/50 PER GROUP.
  • 2 years (Gavage)  (C06155A)  Report Complete 
    • TR-312 (NIH Number: 86-2568)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CASRN 109-69-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,60,120 M: 0,500,1000 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (297558)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (048570)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Inconclusive 
  • Salmonella  (684822)  Completed 
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Negative 
  • Salmonella  (767736)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.