National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10090-f

Testing Status of gamma-Butyrolactone - 10090-F

 

CASRN: 96-48-0

Formula: C4-H6-O2

Synonyms/Common Names

  • 2(3H)-Furanone, Dihydro- (8CI)(9CI)

Known Uses

Intermediate in the synthesis of polyvinylpyrrolidone, dl-methionine, piperidine, phenylbutyric acid, and thiobutyric acids. Solvent for resins. Constituent of paint removers. Textile aids. Drilling oils. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C55878)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 75, 150, 300, 600, OR 1,200 MG/KG M: 0, 87, 175, 350, 700, OR 1,400 MG/KG ; 5/SEX/SPECIES.
  • 13 weeks (Gavage)  (C55878)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 56, 112, 225, 450 OR 900 MG/KG M: 0, 65, 131, 262, 525, OR 1,050 MG/KG; 10/SEX/SPECIES.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55878)  Report Complete 
    • TR-406 (NIH Number: 92-3137)  (Peer Review Approval 07/09/1991A )
      Toxicology and Carcinogenesis Studies of g-Butyrolactone (CASRN 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: MR: 0, 112, OR 225 MG/KG FR: 0, 225, OR 450 MG/KG M: 0, 262, OR 525 MG/KG; 50/SEX/SPECIES.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (516280)  Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (550692)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (896754)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (910246)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
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