National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10093-s

Testing Status of D-Carvone - 10093-S

 

CASRN: 2244-16-8

Formula: C10-H14-O

Synonyms/Common Names

  • 2-Methyl-5-(1-methylethenyl)-2-cyclohexen-1-one

Known Uses

Found in oil of caraway, other plants; flavoring agent for food & beverages; fragrance in perfumery & soaps (Food, Cosm Tox. 1979). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55867A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55867A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 93, 1500 MG/KG/30 MALES PER GROUP/10 FEMALES PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55867A)  Report Complete 
    • TR-381 (NIH Number: 90-2836)  (Peer Review Approval 06/27/1989A )
      Toxicology and Carcinogenesis Studies of d-Carvone (CASRN 2244-16-8) in B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 175, 375, M: 0, 375, 750 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (983543)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (544172)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
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