National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10097-h

Testing Status of Chlordecone - 10097-H

 

CASRN: 143-50-0

Related: CHLORDECONE ALCOHOL (CAS 1034-41-9)

Formula: C10-Cl10-O

Synonyms/Common Names

  • 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
  • Kepone

Known Uses

Insecticide for fruit trees; as a fungicide; base material for the manufacture of kelevan. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00191)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00191)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00191)  Report Complete 
    • TR-000 (143-50-0)   (Peer Review Approval NA)
      Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CASRN 143-50-0)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0447)  Completed 
    • Citation: Bungay PM, Dedrick RL, Matthews HB. Enteric transport of chlordecone (Kepone) in the rat. J Pharmacokinet Biopharm. 1981 Jun;9(3):309-41.Pubmed Abstract
    • Rats: Sprague Dawley
  • C. elegans  (W10097)  Completed 
    • C. elegans

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (232320)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (163075)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (663576)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (795821)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Gavage & Intraperitoneal Injection)  (NTA94020)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats: F344/N
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.