National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10101-t

Testing Status of Chlorpromazine hydrochloride - 10101-T

 

CASRN: 69-09-0

Formula: C17-H19-Cl-N2-S.Cl-H

Synonyms/Common Names

  • 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, hydrochloride (1:1)

Known Uses

Tranquilizer, antiemetic, phenothiazine antipsychotic agent.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (333439)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (447840)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (TER82055)  Completed 
    • Citation: Teratologic Evaluation of Chlorpromazine Hydrochloride Administered to Fischer 344 Rats on Gestational Days 6 through 15
    • Female Rats: F344/N
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 5, 15, 30, 45 MG/KG/DAY.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER82056)  Completed 
    • Citation: Teratologic Evaluation of Chlorpromazine Hydrochloride Administered to CD-1 Mice on Gestational Days 6 through 15
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 2.5, 5, 15, 30 MG/KG/DAY.
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