National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10103-c

Testing Status of Corn oil - 10103-C

 

CASRN: 8001-30-7

Formula: N/F

Synonyms/Common Names

  • Mazola oil

Known Uses

Salad and cooking oil, margarine production, pharmaceutical preparations, in nonyellowing enamel paint, defoaming agent in paper/paperboard manufacturing, vehicle for experimental diets and test compounds. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C00577)  Report Complete 
    • TR-426 (NIH Number: 94-3157)  (Peer Review Approval 12/01/1992A )
      Comparative Toxicology Studies of Corn Oil, Safflower Oil, and Tricaprylin (CASRNs 8001-30-7, 8001-23-8, and 538-23-8) in Male F344/N Rats as Vehicles for Gavage
    • Rats: F344/N
    • Dose: RATS ONLY: 0, 2.5, 5, 10 ML CORN OIL/KG FOR 103 WEEKS./50 PER GROUP.

Genetic Toxicology

  • Comet Assay (Gavage)  (G10103C)  On Test 
    • Rats: Harlan Sprague-Dawley
  • Micronucleus  (G10103B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male No Call 
  • Micronucleus  (G10103)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male No Call 
  • Salmonella  (655449)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Dominant Lethal (Female) (Intravenous)  (DLF015)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984).
    • Female Mice: C3H X C57BL
    • Mice Female Negative 
  • Dominant Lethal (Female) (Gavage)  (DLF016)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984).
    • Female Mice: C3H X 101
    • Mice Female Negative 
  • Dominant Lethal (Female) (Gavage)  (DLF017)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984).
    • Female Mice: SEC X C57BL
    • Mice Female Negative 
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER87118)  Completed 
    • Citation: Teratologic Evaluation of Corn Oil or Distilled Water Administered to CD Rats on Gestational Days 6 through 15
    • Female Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Negative 
    • Dose: 5 ML/KG/DAY.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER87119)  Completed 
    • Citation: Teratologic Evaluation of Corn Oil or Distilled Water Administered by Gavage to CD-1 Mice on Gestational Days 6 through 15
    • Female Mice: Swiss
    • Mice Maternal Negative 
    • Mice Fetal Negative 
    • Dose: 0, 3, 10 MIC.O./KG OR 0, 5 ML DIS.W/KG.
  • Total Reproductive Capacity (Gavage)  (TRC98029)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice: B6C3F1
    • Mice Female  - CONTROL
    • - CONTROL

Toxicogenomics

  • Microarray Analysis (Gavage) Selected (T10103)  
    • Liver Transcriptome Changes During Estrus Cycle
    • Rats: Wistar Han
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